The environment and its changes, as well as the relationships maintained by human societies with their environments, determine health inequalities and their dynamics at different spatial and temporal scales. The spatial systems resulting from the complex interaction of these determinants must be understood in a systemic and holistic way and, therefore, interdisciplinary and multi-scalar, including ecology, epidemiology, human and animal health, geography, geoprocessing, data modeling sciences, etc. Thus, the objectives of LMI Sentinela are: to structure, strengthen and sustain an integrated approach through Geography – Environment – Climate – Health in Brazil, based on training, research and public policies; reinforcing the international visibility of the Brazilian teams that will work in partnership in this project.